Until now, the genetic analysis of embryos was carried out using the technique of Preimplantation Genetic Diagnosis or PGD, which consists of the extraction of a few cells from each of the embryos that we want to analyze to know their chromosomal endowment and to know if they present certain genetic alterations.
Since embryo manipulation is necessary to perform this analysis, DPG is therefore an invasive test. The biopsy of the embryos is essential to obtain the cells to analyze.
Recently, a new non-invasive approach has been developed for the genetic study of embryos. This new technique is based on the embryos, during their development in vitro, releasing DNA fragments into the culture medium, especially from the 4th day of their development (morula stage). In this way, by analyzing the embryonic free DNA that can be obtained from the culture medium where the embryos have developed, we will be able to study their genetics.
The reliability of the results is not yet 100% comparable to those obtained by DPG, however, the latest studies show a high concordance between the results of both techniques. Therefore, it is already contemplated to use this new non-invasive analysis as a way to prioritize the transfer of those embryos with a greater probability of having an adequate genetic endowment.
If future studies follow the trend observed so far, the application of this non-invasive embryo analysis could reduce the number of cycles required to achieve pregnancy.
If you have any questions or want to start a treatment with us, you can contact us by sending an email to info@centromedicomanzanera.com or through the contact forms on our website: https://www.centromedicomanzanera.com/formulario-es/
María Pombar Gómez
Embriologyst
PICTURE: https://embracefertility.org/non-invasive-genetic-testing-of-embryos/
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